The occurrence of coronary artery lesions in Kawasaki disease based on C-reactive protein levels: a retrospective cohort study

Abstract Background This study aimed to assess the occurrence of coronary artery lesions (CAL) in patients with Kawasaki disease (KD) according serum C-reactive protein (CRP) levels. Methods retrospective analysis was based on nationwide survey KD conducted Republic Korea between 2015 and 2017. We enrolled 9131 defined low (< 3 mg/dL) high (≥3 CRP groups. Demographic data, clinical characteristics, z-scores, scores Japanese criteria for CAL were compared two Logistic regression used identify risk factors. Results The group accounted 23% patients. mean age at diagnosis higher (34.4 ± 24.9 vs 31.7 24.8 months, p < 0.001). Fever duration before treatment not significantly different groups (5.1 1.7 days vs. 5.2 2.1 days; = 0.206). A non-response intravenous immunoglobulin found 1377 (20.1%) 225 (11.7%) groups, respectively ( 12.9 18.3% patients, 0.001), z-scores; 9.9 12.5%, acute phase. giant aneurysm ratio similar 1.0). Conclusions occurred both CRP. Therefore, should be carefully monitored regardless their